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Why are the side effects of the second dose of COVID-19 vaccine more serious?



The use of the COVID-19 vaccine may have mild to moderate side effects. If two doses are injected, the side effects after the second prick may be more serious than the first one.

Experts say this is normal and should not prevent people from completing the vaccine series.

In the trial of Moderna and Pfizer vaccines, more people experienced side effects after the second dose of the vaccine.

“Our early advice to people who are getting vaccinated is that when you get the second vaccination, you can tell your employer,’Hey, I’m getting the second vaccination. Maybe I’m on sick leave, so you It can be foreseen, and you are not afraid of it,” said Dr. Peter Chin-Hong, an infectious disease expert at the University of California, San Francisco.


In Pfizer’s clinical trial, the number of people experiencing chills and joint pain after the second dose of the drug was twice the original number. Compared with Moderna, the number of people who received the second dose of Moderna shivered was about five times as many as those who received the first dose. Compared with the second vaccine, redness, swelling and fever at the injection site of the second vaccine are also more common.

Dr. Melanie Swift, co-chair of the Mayo Clinic’s COVID-19 vaccine distribution and distribution working group, said the side effect is that the body has developed immunity to the virus.

Swift said that with the first dose of the vaccine, your immune system starts to work and can recognize the spike protein produced by the COVID-19 vaccine for the first time.

She said: “Your body will build this immune memory.” “It’s like your body is walking,’COVID, now I have your phone number, and now I am ready for you.'”

After the second dose, your body will produce spike protein and release antibodies.

She said: “Your immune memory cells have not been forgotten, they are ready for a strong immune response.”

Qin Hong compared the experience of getting two doses of COVID vaccine to turning on a computer.

Chin-Hong explained: “With the first dose of the drug, you turned on the computer, but then it was on standby.” “Then the second shot, it was immediately activated and ready to fight the intruder, and it considered the spike protein It’s an intruder. This effect is greatly enhanced, which is usually a good thing, because it just means that your immune system is working.”

The human body’s response to the vaccine is normal. With two doses of Moderna and Pfizer vaccines and a single dose of Johnson & Johnson, the most common reaction among the recipients in the trial was pain at the injection site. In all other vaccines, you may experience fatigue, headache, muscle pain, chills, fever, and nausea with all vaccines.

Swift said: “The side effects are a good sign.” “But it confuses people because many of these symptoms are COVID symptoms, but the difference is that COVID does not have a respiratory system. With the vaccine, you won’t have a cough, nose You won’t have a runny nose, and you won’t lose your taste or sense of smell.”

Side effects usually go away on their own after one to two days.

Chin-Hong said that all vaccine trials have shown that, according to research, side effects are more common in women and young people.


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