Regardless of what celebrities and Instagram influencers say in their stories while on vacation, we are still in the midst of a global pandemic. Yes, the coronavirus is flooding, and the world is waiting for many of its competitors to propose completely effective but not almost all vaccines. However, although most of the efforts to contain and contain the spread of the virus have been invested in the above competition, scientists at Columbia University, Cornell University and other medical experts have managed to develop a nasal spray that can inactivate people. Agent. Viruses can infect cells before.
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According to Forbes, this may be a “breakthrough that we need to end Covid-1
Like any other virus, the SARS-CoV2 virus also needs to fuse with the cell membrane to replicate itself. During this process, the virus injects into its RNA genome and eventually kills the original host cell. But the lipoprotein in the spray “inserts itself into the spike protein, sticking to a chain that would otherwise bind to the receptor and cause the virus to infect the cell.”
It sounds promising, but this small study (published as a preprint of bioRxiv) has not yet been tested in humans. In fact, it was used on a pile of ferrets and 3D models of human lungs. Among the ferrets susceptible to human respiratory infections, a few received real lipoprotein sprays, and the rest received placebo treatment. According to observations, people receiving drug treatment are indeed infected with the virus.
The study pointed out: “Containing the COVID-19 pandemic requires reducing the spread of the virus. SARS-CoV-2 infection is triggered by the membrane fusion between the virus and the host cell membrane mediated by the viral spike protein. We designed a dimer A lipopeptide fusion inhibitor, this inhibitor can prevent the new emerging coronavirus infection from the critical first step and prove that it can completely prevent the SARS-CoV-2 infection in ferrets.”
Researchers include Rory D. de Vries, Katharina S. Schmitz, Francesca T. Bovier, Danny Noack, Bart L. Haagmans, Sudipta Biswas, Barry Rockx, Samuel H. Gellman, Christopher A. Alabi, Rik L. de Swart, Anne Moscona and Matteo Porotto believe that “the spray will linger around the nose and lung cells for about 24 hours.”
“Under strict conditions, the daily intranasal administration of ferrets into the nasal cavity completely prevented the direct contact and transmission of SARS-CoV-2 during cohabitation with infected animals, which resulted in 100% of untreated animals being infected. These lipopeptides It is highly stable and non-toxic, so it can easily be transformed into a safe and effective intranasal prevention method to reduce the spread of SARS-CoV-2.”
But this is not the best part. In an article in the New York Times, Dr. Moscona said: “Lipoprotein can be cheaply made into a white dry powder that does not require freezing.” “A doctor or pharmacist can mix the powder with sugar and water to create a nasal spray. Because lipopeptides can be shipped in dry powder form, they can be used even in rural areas in poor countries that lack cold storage.”
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Cover image: Bhavya Poonia / Mashable India