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The HIV vaccine based on Moderna COVID vaccine has achieved promising results



Refinery 29

The COVID-19 vaccine may bring some surprising benefits

Within a few hours of the first US approval of the COVID-19 vaccine for emergency use, I spoke with epidemiologists and medical experts on the phone, and they detailed the expected advantages of widespread vaccination: fewer deaths and fewer severe cases. COVID-19, so the hospital will not be so overwhelmed. The people I spoke to called the news “the light at the end of the tunnel.”

; They say that shooting as many shots as possible is the key to gaining immunity to the herd, so we can eventually return to the normal state before the pandemic. However, as the three vaccines approved in the United States (Pfizer/BioNTech, Moderna and Johnson & Johnson) have been rolled out to more than 100 million Americans, we already know that vaccination may bring more unexpected benefits than experts initially expected . Here are just some of them. Many vaccines provide at least some protection against the variants. Although the rapidly launched vaccines make the future look brighter than before, at least there is an ominous shadow over us: the COVID-19 variants, which are the SARS-CoV-2 virus. Experts say that some viruses may be more contagious than the original virus, or even more deadly. You may have heard of the B.1.1.7, B.1.351 and P.1 variants, which attacked the UK, Brazil and South Africa respectively. When these strains were first discovered, experts were not sure whether existing vaccines could resist them. Fortunately, studies have shown that two messenger ribonucleic acid (mRNA) vaccines (Pfizer and Moderna) are both very effective against the B.1.1.7 variant. Although these vaccines are four to seven times less effective against P.1 variants, they may still provide a “protective pad”, especially after two doses. Anthony Fauci, MD, Director of the National Institute of Allergy and Infectious Diseases , Said at a White House press conference. Early research pointed to the idea that both the mRNA vaccine and Johnson & Johnson are less effective against the B.1.351 variant. However, earlier this month, Pfizer released test data showing that their vaccine is effective in preventing B.1.351 in South Africa and can prevent COVID-19 100% effectively. For the sake of safety, the developers of all three vaccines that have been approved in the United States are working quickly to make their formulations more effective against the variants, and are trying to boost injections. Preeti N. Malani, MD, Chief Health Officer of the University of Michigan said: “All vaccines are currently very effective against serious diseases and may provide some protection for this variant.” “I am optimistic, but we still need to be careful now. “The National Institutes of Health pointed out that some COVID-19 long-distance transporters say that the vaccine is relieving their symptoms. 10% to 30% of people who get COVID-19 will experience long-term symptoms. Some people who have solved some long-term problems now say that this vaccine helps relieve their symptoms. ProHealth Director of Infectious Diseases, Dr. Daniel Griffin, told CNN: “There have been a lot of reports, hundreds of reports about patients we have been treated with COVID.” “They reported that their long-term symptoms of COVID were obvious after vaccination , It’s not even completely relieved.” In a survey of 345 people, most of them lived in the UK and were still women. 32% of people said that their lingering COVID symptoms improved two weeks or more after their first vaccination. Although no peer-reviewed research has been published yet, other researchers are also working on it. It is too early to say why vaccines can relieve long-term symptoms. People who cannot completely eliminate the virus from their bodies may encounter lingering problems; the vaccine can induce a strong response from the immune system, thereby completely eliminating the virus that causes COVID-19. Prolonged COVID symptoms may also be caused by some form of immune dysfunction. Dr. Marani explained that this vaccine may trigger an “immune reset” and thus solve the problem. “We still don’t understand why some people are at risk [long COVID]She added, “But in fact, we even heard anecdotes about the relief of symptoms after vaccination is very promising.” The COVID-19 lens paved the way for future vaccine research. In 1796, British doctors developed the first vaccine for “smallpox”. Notes from the Association of American Medical Colleges. Until 2020, all vaccines (minus the pus) use a similar approach-patients often get infected with an inactivated or attenuated version of the virus itself. However, the information that scientists learned while developing the mRNA COVID-19 vaccine may pave the way for future vaccines, including vaccines against diseases such as HIV, influenza, Zika virus and rabies. (An analysis in the journal Nature shows that human trials of mRNA vaccines against these diseases before CODID-19 are already underway). Unlike other vaccines, the working principle of mRNA vaccines is to instruct our cells to make proteins or protein fragments, thereby helping our body recognize the key fragments of the virus and produce an immune response to it. Dr. Dan Barouch, director of the Harvard Medical School’s Center for Virology and Vaccines, told AAMC: “Due to COVID-19, the field of vaccines has undergone permanent changes and has been eternally developed.” Pregnant women may be. Passing Immunity to Newborns Although pregnant women were not included in vaccination trials for ethical reasons, more than 69,000 pregnant women in the United States have been vaccinated so far. Early studies have shown that this vaccine may be safe during pregnancy Effective. Not to mention, the preliminary findings of the American Journal of Obstetrics and Gynecology also indicate that if pregnant women receive the vaccine as expected, they may also provide protection for their newborns. This is based on other studies that show that the vaccinated person may pass antibodies against COVID-19 to the fetus through the placenta. More research is needed to confirm these findings, but if this is true, it will be big news because some newborns are more susceptible to serious illness and it is unlikely that the vaccine will be approved for this age group in the near future . Vaccination may make people less infectious. In most cases, the COVID-19 vaccine protects people from the virus from the beginning. An Israeli study showed that, in rare cases, someone who does test positive behind the jaw may have a much lower viral load than someone who has not been vaccinated (fair warning has not been peer-reviewed). A low viral load (referring to the number of viruses detected in someone’s system) has two benefits: they have a lower risk of serious illness, and they may not spread the virus as easily as other people. Vaccines can alleviate COVID anxiety. Of course, we know that getting a vaccine will relieve it-but many people say that they don’t want to feel good after the injection. Dr. Marani said: “In the past year, people have been afraid of doing ordinary things, such as seeing their friends and family, and they are really alone.” “Loneliness and loneliness are also great health risks. , They can cause physical harm to young and old people.” For some people, getting vaccinated and relieving COVID anxiety is like taking a deep breath of fresh air for the first time in a year. New Yorker Alexa Nikiforou said: “After the second shot, I had an’ahha’ moment. Everything is looking up. We are moving towards a new normal, no matter what the new normal.” “There is a feeling of hope. Like what you saw? 9 common vaccine myths are debunked. What happens if you use two different vaccines?


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