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Home / Health / The Centers for Disease Control and Prevention (CDC) reported that the California variant may cause more serious diseases

The Centers for Disease Control and Prevention (CDC) reported that the California variant may cause more serious diseases



A new report released by the Centers for Disease Control and Prevention on Wednesday shows that the first variant of COVID-19 found in California is more likely to cause serious illness than other variants and may weaken antibody treatment.

According to the New York Times, the B.1.427/B.1.429 variant was discovered in California in December and continues to be the main variant in the state. It has spread to many states across the country.

The report documents the Colorado Department of Public Health’s analysis of B.1.427/B.1.429 cases that occurred in Colorado from January 4 to March 20. They found that the virus strain rose from 3% to 4% of cases in late January to 20% to 22% of cases in early March.


B.1.427 and B.1.429 refer to two different lineage names, but according to the California Department of Public Health, these strains are closely related and are often referred to as California variants or “West Coast strains.” B.1.427 / B.1.429 are associated with a transmission increase of approximately 20%. In contrast, the B.1.1.7 variant originally discovered in the UK is believed to have an increased 50% transmission.

UCSF infectious disease expert Dr. Peter Chin-Hong said that the findings presented in the report are not surprising. Jin Hong, who was not the author of the study, wrote in an email: “California people should pay special attention, but don’t pay attention immediately for various reasons.” The vaccination situation is different from the past. Although the overall response has weakened, the currently approved vaccines are still able to resist this mutation very well. In general, the vaccine produces more antibodies than we need to protect. Against SARS CoV2 ).”

He added that the concern is that individuals who have not been vaccinated, especially those who are older or suffer from comorbid diseases, may face a higher risk of serious illness and death using this variant. Chin-Hong wrote: “For these people, this is a completely different time from a year ago.”

The CDC report includes an analysis of 327 B.1.427/B.1.429 specimens collected by the Colorado Department of Public Health in approximately three months. According to the report, 91% of the 211 patients with symptom information were symptomatic and 14% were hospitalized. There were 8 deaths (2%), and according to available data, there were 7 (2%) vaccine breakthrough cases.

“Although the variation data for Colorado comes from a convenience sample, compared with the nationally estimated symptomatic disease and 5% hospitalization rate of patients who tested positive for SARS-CoV-2, these data indicate that The author concludes: “This may be more likely to cause obvious and serious diseases than a nationwide pedigree. ”

The author also wrote that B.1.427/B.1.429 may be resistant to monoclonal antibody therapy bamlanivimab. The Colorado Department of Health issued a recommendation on March 22 to advise against the use of bamlanivimab for monotherapy, and last month, the U.S. Food and Drug Administration (FDA) revoked the emergency use authorization of the product for monotherapy.

Although these findings are worrying, a recent report in the Los Angeles Times indicated that the existence of California B.1.427/B.1.429 may help the state.

“Although the highly infectious British variant (B.1.1.7) is believed to have caused serious problems in the recent Michigan surge, the California variant (B.1.427 / B.1.429) may prevent the British variant in California, “The Los Angeles Times reported. “Although the California variant is more contagious than the traditional strain, it is not as contagious as the British variant, and if you have to choose between the two, then the California variant will be a better way to deal with it.”


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