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Study of nearly 2,000 Marine Corps recruits found asymptomatic SARS-CoV-2 transmission



SARS-COV-2, COVID-19

Color scanning electron micrograph of apoptotic cells (green) severely infected with SARS-COV-2 virus particles (yellow) isolated from patient samples. The image was taken at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: NIH / NIAID

A study of nearly 2,000 Marine Corps recruits showed that they received quarantine before starting basic training. Despite the quarantine measures, SARS-CoV-2 (the virus that causes COVID-1

9) was transmitted asymptomatically. ) Asymptomatic transmission.

These findings have important implications for the effectiveness of public health measures to suppress the spread of COVID-19 among young people, whether in military training, schools, or other aspects of the pandemic.

Researchers from the Icahn School of Medicine at Mount Sinai and the Naval Medical Research Center conducted a two-week surveillance and quarantine on the newly recruited Marine Corps recruits.The research results were published on November 11 New England Journal of MedicineResearch shows that very few infected recruits have symptoms before being diagnosed with SARS-CoV-2 infection. Despite the implementation of many best-practice public health measures, transmission still occurs, and the diagnosis is only made through scheduled tests. Rather than by testing for symptoms.

Dr. Stuart Sealfon, professor of neurology at the Icahn School of Medicine, said: “We are honored that the US Navy has provided us with the opportunity to collaborate on the research of Marine Corps recruits SARS-CoV-2. At Sinai. “This is a very difficult infection for young people to suppress. , Even if they wear masks, social distancing and other mitigation measures are closely monitored. We found that routine testing that does not rely on symptoms can also identify carriers that can transmit SARS-CoV-2. We hope that this information will help us develop more effective measures to ensure the safety of military facilities and schools. “

Research data shows that even under strict military order isolation and public health measures, the virus can spread asymptomatically. Compared with other youth environments such as university campuses, the virus is most likely to gain better compliance. The researchers pointed out that daily temperature and symptom checks cannot detect infections among recruits, and that the virus is mainly spread in a given group, and trainees are often close to each other.

The focus of the study was on 1,848 study participants recruited from nine different Marine Corps recruitment classes between May 15 and the end of July, each class containing 350 to 450 recruits. Before receiving basic training, after two weeks of self-isolation at home, participants were provided with a prospective, longitudinal study registration. After they arrive, they must take strict group quarantine measures for the two-person room for two weeks (research period) before starting the actual training. The supervised group isolation was carried out at a university that was used for this purpose only. Each recruit class is located in a different building and has different dining times and training schedules, so there is no interaction between classes.

The weekly courses are further divided into 50 to 60 rows. During the study, all candidates wore masks, had a social distance of at least six feet, and washed their hands regularly. Each candidate had only one roommate. Most of their guidance, including exercises and learning military customs and traditions, are conducted outdoors. After the isolation of each class and before the arrival of the next class, all rooms and public areas of the dormitory were deeply cleaned with surface bleach.

To determine the prevalence and transmission of asymptomatic and symptomatic SARS-CoV-2 during surveillance and quarantine, a nasal swab (PCR) test authorized by the U.S. Food and Drug Administration for emergency use was used after arrival 2 Participants were tested within days, 7 days and 14 days. And the Drug Administration. After analyzing the viral genomes of the infected recruits, multiple clusters that are correlated in time, space, and epidemiology were identified, which revealed multiple local transmission events during the isolation period.

“The identification of six independent transmission clusters defined by six different mutations showed that there were multiple independent SARS-CoV-2 introductions and outbreaks during surveillance quarantine,” Dr. Harm van Bakel, Assistant Professor of Genetics and Genomic Sciences Say. Icahn School of Medicine at Mount Sinai. “The data from this large-scale study shows that in order to reduce the spread of coronavirus among the population and prevent spillover to the wider community, we need to establish extensive initial and repeated surveillance tests for all individuals, regardless of symptoms.”

An in-depth understanding of the COVID-19 characteristics of military personnel and the spread of SARS-CoV-2 is related to the development of safer methods for related environments composed mainly of young people (such as schools, sports fields, and camps).

“Our research emphasized the ability of naval medical research to deploy and overcome many logistical obstacles during the pandemic, and quickly established itself with research approved by the Institutional Review Board. These results will improve the medical condition of our Marine Corps and should help To provide information on the public health policy of the entire country, the Navy, the Ministry of National Defense, and society as a whole to reduce the spread of SARS CoV-2.” Andrew Letizia, Deputy Director of the Bureau of Infectious Diseases and Chief Researcher of the Naval Medical Research Center (Andrew Letizia) ,Medical PhD.


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Citation: A study of nearly 2,000 Marine Corps recruits showed that asymptomatic SARS-CoV-2 spread (November 11, 2020) on November 12, 2020 from https://medicalxpress.com/news/2020-11 -marine-reveals-asymptomatic-sars-cov-retrieved transmission.html

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