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Study finds nearly 300 children with inflammatory diseases related to Covid-19



TThe research team in the United States reported that nearly 300 cases of significant side effects of Covid-19 occurred in children. This condition is called multisystem inflammation syndrome or MIS-C. Although researchers have previously reported the disease, these papers mark the first attempt to measure the frequency of this side effect and its impact on children developing the disease.

The study, published in the New England Journal of Medicine, describes a disease that sometimes causes severe inflammation two to four weeks after infection after suffering from Covid-19, affecting multiple organ systems. Most children used to be healthy.

In a study led by researchers at Boston Children̵

7;s Hospital, 80% of children with the disease required intensive care, 20% required mechanical ventilation, and 4 children (ie 2%) died. In the second study, researchers from New York State found that a similar percentage of 99 children with the syndrome required ICU care and two children died. In two studies, many children developed cardiovascular and coagulation problems, and many developed gastrointestinal symptoms. A high percentage of people also have rashes.

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Adrienne Randolph, an ICU physician at Boston Children’s Hospital and senior author of one of the papers, said: “Our children are really very sick.” The paper was based on reports from 26 states .

Manish Patel of the Covid-19 Response Team at the Centers for Disease Control and Prevention said the message to parents is that they should be aware of fever and rash in children who have recently suffered from Covid-19.

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Patel, author of Randolph’s paper, said: “I think it’s important to be vigilant.” “I will have a fever and a rash, especially in areas where you have a coronavirus infection (SARS-CoV-2 infection). The threshold for consultation is lower.”

Overall, children seem to suffer from SARS-CoV-2 less frequently than adults, and they are less ill.

But in late April, doctors in London issued a warning to the world that some children with Covid-19 seem to continue to develop what looks like Kawasaki disease, and this inflammation will attack the heart. The so-called KD is usually seen in children under 5 years old. Soon after, doctors in New York began to report cases.

In mid-May, the Centers for Disease Control and Prevention (CDC) required doctors across the country to monitor children’s multi-system inflammation syndrome.

The nearly 300 cases identified in these two studies have some similarities with KD, but there are also differences. There are very few children under 5 years of age. In larger studies, the average age of children was 8 years old. 42% of children in the New York cohort are between 6 and 12 years old.

The researchers report another difference: Although KD disproportionately affects the children of Asians, the MIS-C cases in the New York cohort have racial and ethnic backgrounds.

“Among our patients, mainly from New York City, 40% are black and 36% are Hispanic. They wrote: “This may reflect a large number of literature reports of SARS CoV-2 infection in black and Hispanic communities The rate rises. “

The New York team estimates that most MIS-C cases occur about a month after the peak of Covid-19 cases in the state. They estimated that between March 1 and May 10, two out of every 100,000 people under the age of 21 confirmed SARS-CoV-2 virus in the laboratory, and the state had MIS-C. During this period, the infection rate of people under 21 years of age was 100,000 322.

An editorial written by Michael Levin of the Department of Infectious Diseases at Imperial College London said that so far, around 1,000 pediatric cases have been reported worldwide. He suggested that more cases may not be documented because the case definition requires evidence of previous Covid-19 infection.

Levin wrote: “The worry is that children who meet the current diagnostic criteria of MIS-C are the’tip of the iceberg’, and even bigger problems may be lurking below the waterline.”

This article has been updated to include information from New York State research.

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