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Scientists warn that about 1.4% of Covid-19 patients will have a stroke



According to the latest data, there will be at least one stroke in every 100 Covid-19 hospitalized patients.

Scholars have found that stroke usually occurs a few days after infection and may affect people who have never shown symptoms of coronavirus.

Those with life-threatening complications are older, but about six years younger than the patients usually seen in the hospital. And strokes from Covid-19 are twice as fatal as normal strokes.

It has also been discovered that potentially unhealthy conditions, such as those caused by high blood pressure and diabetes, are risk factors for coronavirus-related strokes.

The findings come from the Stroke Research Group at the University of Cambridge, which reviewed existing evidence on Covid-1

9 and stroke. The researchers analyzed a total of 61 studies, covering more than 100,000 patients hospitalized with the coronavirus.

Data from hospital patients shows that one in every 100 Covid-19 patients will have a stroke

Data from hospital patients shows that one in every 100 Covid-19 patients will have a stroke

The results of the study were published today in the International Journal of Stroke.

Professor Hugh Marcus, head of the Cambridge Stroke Research Group, said that the incidence of stroke in Covid-19 patients is very low.

But he added: “The scale of the pandemic means that thousands of people may be affected worldwide.”

The study found that 14 out of every 1,000 strokes occurred-equivalent to 1.4 out of 100 hospitalized patients.

The most common type of stroke is an acute ischemic stroke caused by a blood clot cutting off the blood supply to the brain.

Brain abnormality is a common phenomenon in “type 19 patients”

Experts warn that brain abnormalities are common in Covid-19, warning that any damage to the organs may be permanent.

Throughout the pandemic, doctors all over the world claim that Covid-19 is not only affecting the lungs.

Dozens of patients suffer from neurological complications, including strokes, headaches and seizures, and heart problems. According to reports, 40% of Covid-19 patients suffer from neurological diseases.

However, despite several studies that warn of clear links, scholars are still confused about how Covid-19 affects the brain.

Researchers at Baylor College of Medicine and the University of Pittsburgh are now adding more and more evidence.

They studied brain scans of more than 600 Covid-19 patients who participated in 18 different studies.

Everyone has an electroencephalogram (EEG), which is a scan that records their brain activity. During the EEG process, small sensors are installed on the scalp to pick up the electrical signals generated when brain cells send information to each other. These signals are recorded by the machine and checked by experts to see if they are abnormal.

The main reason for giving patients an EEG is to determine the cause of certain symptoms, such as seizures, memory disorders, confusion or language disorders.

Among patients undergoing EEG examinations, 88% had abnormal readings. The likelihood of pre-existing EEG abnormalities is very low, and researchers believe that most EEG abnormalities are new.

About one-third of EEG patients have neuroimaging abnormalities-MRI or CT scans can visually show the brain.

The research team acknowledged that this connection may be related to older patients, underlying neurological diseases, or severely ill patients.

The most common problem in EEG scans is “diffuse slowdown”, which is related to difficulties in consciousness, concentration, memory, and understanding.

Dr. Zulfi Haneef, Assistant Professor of Baylor Neurology, said: “As we all know, the brain is an organ that cannot be regenerated, so if you have any damage, it is likely to be permanent or you will not be able to fully recover.”

However, in this review, 56.8% of EEG follow-up studies showed that patients have improved. However, in some cases, symptoms can worsen.

Although there is no evidence, scientists say they believe that the changes in the brain are caused by the coronavirus, not a “coincidence.”

They believe this is because EEG analysis also shows that 30% to 50% of abnormalities involve the frontal area, which is the nasopharynx immediately behind the nose, and the nasopharynx is directly behind the nose.

This shows that the virus enters the frontal lobe of the brain through the nose, causing direct damage.

Co-author Dr. Arun Raj Antony from the University of Pittsburgh told MailOnline that “the abnormal phenomenon is entirely caused by Covid” because “in most of these patients, EEG manifestations are symptomatic and all patients tested positive for Covid.” .

Dr. Hanev said: “Before, when we saw this as a group, we were not sure if it was just a coincidence, but now we can confidently say that it is connected.”

The findings are published in “Epilepsy: The European Journal of Epilepsy”

Cerebral hemorrhage is caused by a ruptured artery in the brain, which is less common.

Most of the patients suffering from fatal incidents have been admitted to the hospital with Covid-19 symptoms and suffered a stroke a few days later.

Patients severely infected with SARS-CoV-2 (the coronavirus that causes Covid-19) are also at greater risk.

However, the researchers warned that many Covid-19 cases are asymptomatic and cause no symptoms at all.

They now recommend that every stroke patient admitted to the hospital be tested for Covid-19 for this reason.

Covid-19 patients who have had a stroke are on average 4.8 years older than those who have not. But according to analysis, they are on average six years younger than non-Covid-19 stroke patients.

The research team pointed out that pre-existing health conditions, such as high blood pressure, diabetes and heart disease, also increase the risk of stroke.

However, experts found that there was no difference in the incidence of stroke between infected men and women, smokers and non-smokers.

Researchers say that strokes related to Covid-19 are more serious than stroke patients usually see and have a higher mortality rate.

Of the 1,655 patients with sufficient data to analyze, 31.5% died. In contrast, the proportion of non-Covid stroke patients is 11% to 12%.

Researchers have provided several possible mechanisms to explain why coronaviruses, once thought to be pure respiratory diseases, cause strokes.

One mechanism may be that the virus triggers an inflammatory response, causing blood to thicken, increasing the risk of thrombosis and stroke.

The other involves ACE2-a protein “receptor” that SARS-CoV-2 uses to break into the cell’s cell surface.

The receptor is usually found in the cells of the lung, heart, kidney, and blood vessel intima. If the virus invades the inner walls of blood vessels, it may cause inflammation, constrict blood vessels and restrict blood flow.

The third possible mechanism is that the immune system overreacts to infection, and the body subsequently releases excessive amounts of proteins called cytokines.

Then, this so-called “cytokine storm” may cause brain damage, and is also thought to damage blood vessels and make platelets more “active”.

An important question is whether the coronavirus directly increases the risk of stroke, or whether stroke patients are already more at risk, and Covid-19 indirectly caused this event.

Dr. Stefania Nannoni, a study author in the Department of Clinical Neuroscience at the University of Cambridge, said: “The situation is complicated.”

For example, many Covid-19 patients may already have an increased risk of stroke, while other factors (such as the mental stress of Covid-19) may contribute to the risk of stroke.

“On the other hand, in some cases, we see evidence that Covid-19 may cause stroke-or at least a risk factor for stroke.

“First of all, there are more SARS-CoV-2 than other coronaviruses and much more than seasonal flu, which seems to be related to stroke.

“Secondly, we found a special pattern of stroke in Covid-19 patients, which indicates that at least some patients have a causal relationship.”

Professor Marcus said: “Clinicians will need to pay attention to the signs and symptoms of stroke, especially in those at special risk, and remember that high-risk patients are younger than expected.”

The research was supported by the Medical Research Council, National Institutes of Health (NIHR), NIHR Cambridge Biomedical Research and the British Heart Foundation.

COVID-19 “may age the brain for 10 years”

An unpeer-reviewed study found that Covid-19 can age the brain for ten years.

Dr. Adam Hampshire of Imperial College London and his colleagues studied more than 84,000 people. They found that in some severe cases, coronavirus infection is associated with a large number of cognitive deficits over the past few months.

The researchers wrote in a report on their findings: “Our analysis… is consistent with the belief that Covid-19 will have chronic cognitive consequences.”

People who recovered, including those who no longer reported symptoms, showed significant cognitive deficits.

Cognitive tests measure the brain’s ability to perform tasks-such as remembering words or connecting points on puzzles. This test is widely used to assess brain function in diseases such as Alzheimer’s disease, and can also help doctors evaluate temporary brain damage.

The Hampshire team analyzed the results of 84,285 people who completed a study called the “British Intelligence Test”.

These findings have not been reviewed by other experts and have been published online on the MedRxiv website.

Researchers say that cognitive deficits “have a lot of influence”, especially among those who are hospitalized for Covid-19.

The worst-case scenario shows that the impact is “equivalent to an average 10-year decline in global performance between the ages of 20 and 70.”

However, scientists who were not directly involved in the study said that the results should be studied carefully.

Joanna Wardlaw, Professor of Applied Neuroimaging at the University of Edinburgh, said: “Before Covid, the cognitive function of participants was not known, and the results did not reflect long-term recovery-therefore, the cognitive Any impact of may be short-term.

Derek Hill, a professor of medical imaging at University College London, also pointed out that the results of this study may not be completely reliable because they were not compared before and after the scores and involved a large number of people who self-reported with COVID -19 years old, without any positive tests.

Professor Hill said: “Overall, this is an interesting but uncertain study on the impact of COVID on the brain.”


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