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Related to Covid



Representative images | nhm.ac.uk
Representative images | nhm.ac.uk

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New Delhi: It is estimated that 50% of the Indian population is less susceptible to severe Covid-19 attacks. This may be because Neanderthals and modern humans were naughty with each other tens of thousands of years ago. Some researchers from Japan and Germany claimed.

According to the researchers behind the study Published in PNAS Last week, nearly half of India’s population A 75,000-character DNA sequence was inherited from the Neanderthals, which is believed to reduce the risk of serious diseases caused by Covid-19.

This study, conducted by researchers at the Graduate School of Okinawa University of Science and Technology (OIST) in Japan and the Max Planck Institute for Evolutionary Biology in Germany, aims to study a genetic variation that is associated with severe Covid-19 and ICU 12 Was admitted in another study conducted in May. It turned out that the variant was the same as the variant found in three different Neanderthal specimens.

This is not the first study to discover the connection between Neanderthals (an ancient human being extinct 40,000 years ago) and Covid in modern humans.

Last July, Learn By researchers in Max Planck Institute for Evolutionary Anthropology It was discovered that more than 60,000 years ago, Neanderthals inherited a portion of the human genome that increased the risk of serious diseases from Covid-19. It is estimated that 30% of South Asians carry this gene sequence.

OIST’s Svante Pääbo said: “It’s amazing that even though Neanderthals were extinct 40,000 years ago, their immune systems still affect us in both positive and negative ways.” statement Publish with research.

Hugo Zeberg, one of the authors of the study, told the Print that nearly 50% of Indians have this DNA sequence. He added that the incidence of this genetic mutation is 49.5% among Gujaratis and 48% among Telugus.


Please also read: Neanderthals are not savages.They are precision workers who can take care of the weak


For thousands of years

Neanderthals evolved in western Eurasia about a million years ago. However, because their genes merged with the human population during the last tens of thousands of years of their existence, they continue to have a biological impact on the physiology of modern humans.

Neanderthals have adapted to the African environment for hundreds of thousands of years. During this time, they may also adapt to infectious diseases.

It is said that the cross between Neanderthals and modern humans-originating in Africa-led to contact Every species is infected with a new virus, and Exchange of adaptive gene variants that provide resistance to these viruses.

For example, it is believed that there are two genetic variants that reduce the sensitivity to Helicobacter pylori (an infectious bacteria that causes inflammation of the stomach and certain types of gastric cancer). Genetic From Neanderthal.

Mentioned earlier Research in July 2020 He said that genetic mutations in the chromosome 3 region inherited from Neanderthals increased the risk of severe illness from SARS-CoV-2 (the virus that causes Covid-19).

Chromosomes are linear structures located inside the nucleus. Humans have 23 pairs of chromosomes. Each chromosome is composed of protein and a single molecule of deoxyribonucleic acid (DNA).

DNA contains specific instructions or genetic codes that make each person unique.

In december research team From the University of Edinburgh Find gene The variant on chromosome 12 reduces the risk of intensive care after infection by approximately 22%.

The research was published in PNAS It was shown last week that this variant is almost identical to the discovery of three Neanderthals-one 50,000-year-old Neanderthal from Croatia, two Neanderthals from southern Siberia, one dating back 70,000 , The other dates back to 120,000 years.

Chromosome 12 spans nearly 134 million DNA building blocks (base pairs) and accounts for 4% to 4.5% of the total DNA in the cell.

The gene variant sequence mentioned in this article is approximately 75,000 base pairs.

Three genes in the 75,000 base pair sequence encode enzymes produced by the virus after infection, which in turn activates other enzymes that degrade the viral genome in the infected cell. In short, three genes can help the body initiate the biological process of virus infection of cells.

“It seems that the enzyme encoded by the caveman variant is more effective and reduces the chance of severe infection with the SARS-CoV-2 virus,” Pääbo said.


Please also read: Neanderthal gifts are good for us humans


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