“A year ago, I tried the Moderna vaccine to see if it is safe. (Spoiler: yes!) Now, on my #COVID vaccine anniversary, I am happy to share that I just received the third dose of vaccine. This An enhanced experiment will reveal (1) whether the vaccine that adapts to the strain can enhance immunity (2) is it safe?
Haydn told CNN in a telephone interview: “It is not yet clear whether this new adjusted version is needed.”
Doctors worry that the coronavirus may end up like the flu, requiring a new vaccine every year because of the rapid mutation of circulating strains and the rapid decline in immunity of the vaccine.
Scott Hensley, an immunologist and vaccine expert at the University of Pennsylvania, said: “It’s matched enough to make us well protected.”
But vaccine manufacturers did not seize the opportunity. Haydon’s trial not only tested the third dose of the Moderna vaccine for special protection against B.1.351 (this is what he got), but also tested the third dose of the original vaccine in some volunteers to see if it was enhanced The immune response is both safe and advantageous.
A Pfizer report last month showed that people who take these two drugs at the same time can maintain strong immunity for at least six months. Experts have spared no effort to point out that this does not mean that immunity will cease after six months. This means that the longest volunteers were tracked in the trial to understand their immunity. Hensley said this may last longer.
Hansley told CNN: “I wouldn’t be surprised if we knew that these vaccines would still produce a strong immune response a year from now.”
“If this is a vaccine we can only get once, I wouldn’t be surprised.”
That would make the vaccine more similar to the vaccine against measles than the flu vaccine. The measles vaccine can protect 96% of people from infection for life.
According to Pfizer, even within six months, the protection against Pfizer’s two-dose vaccine remained above 91%. It released detailed information in a statement, rather than an official scientific publication, and the data only covered thousands of people. Experts say, however, if it persists, it shows that both Pfizer and Modena vaccines can cause a long-lasting immune response.
Hansley said the technology used in both vaccines-delivering genetic material called messenger RNA called mRNA-is particularly effective.
“The antibody response caused by these mRNA vaccines is very high. We have learned about other mRNA vaccines that have been tested in animal models. We know that the lifespan of these antibody responses is very long and will not decline over time. Hensley said his laboratory has been testing experimental mRNA vaccines for many years.
Although the coronavirus vaccine is of course new-this virus has only appeared since the end of 2019-mRNA technology has been studied for many years and used to make vaccines against influenza, Ebola and Zika virus.
Several studies have shown that this can be done with the coronavirus vaccine.
Another study conducted in the New England Journal of Medicine in February showed that blood collected from people who received the Pfizer/BioNTech Covid-19 vaccine continued to produce an immune response against B.1.351.
Scott said: “Although we do not know the exact level of neutralization required to prevent Covid-19 disease or infection, our experience with other vaccines tells us that Pfizer vaccine is likely to The new variant provides relatively good protection,” Weaver, director of the Institute of Human Infection and Immunity at the University of Texas Medical Branch, told CNN at the time.
Although he participated in clinical trials that required regular blood draws to check his immunity, Haydn did not know how well he protected against the virus.
Haydn said: “I know that in the early stages of the trial, I and all the participants were indeed developing neutralizing antibodies, the kind of antibodies you were looking for. It became clear many months ago.” “But I was not told about this. The level of the antibody and how the level changes over time. This is one of the main contents evaluated by the study.”
He had a strong reaction to the first round of vaccination and said that the third dose he had just received also caused some effects.
He said: “Counterfeiting is the right way to describe my symptoms.” He added: “I ended up with fever, chills, a little nausea, and headache.”
Immunologists say that this is a signal that the immune system responds to the vaccine, although people who have no symptoms can also have an immune response, so these symptoms do not seem to indicate that someone is responding better than someone who does not have a fever.
Haydn doesn’t know whether his reaction this time can explain what immunity he still has after taking the first dose a year ago.
What he knows is that he cannot show a state of complete immunity. Therefore, whenever he goes out, he still wears a mask and almost avoids all travel.
Hayden said: “We live in a world where most people are not vaccinated. The fact that you have been vaccinated does not bring you any change.”
He added: “We still have to take the same precautions as people who have not been vaccinated.” Although your risk of going to the hospital is greatly reduced, spreading the virus is still a major problem. Only recently did we begin to collect data (showing) that the rate of transmission of the virus by vaccinated people is also much lower. Therefore, this is a recent discovery and a very good signal. “