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How exercise affects immunity and reduces cancer risk



Therefore, recently, a group of scientists from Stockholm Karolinska Institute and other institutions began to suspect white blood cells. White blood cells are part of the immune system. They play a key role in our anti-cancer defense by paying attention, navigating and often destroying malignant cells. Researchers have known for some time that different types of immune cells tend to target different types of cancer. However, little is known about whether and how exercise affects these immune cells, and whether these changes may promote the carcinogenic effects of exercise in some way.

Now, for this new study published in eLife in October, Swedish scientists have decided to inoculate mice with different types of cancer cells and let certain rodents run, while other sedentary mice learn more. many. After a few weeks, the researchers found that some runners showed little signs of tumor growth. More interestingly, most of these mobile mice have been vaccinated with cancer cells that are known to be particularly vulnerable to specific types of immune cells (called CD8 + T cells), which tend to fight against certain forms of breast Cancer and other solid tumors.

Researchers speculate that exercise may have special effects on these immune cells.

To find out, they then chemically blocked the action of these T cells in animals carrying tumor cells and allowed them to run. After a few weeks, animals without functional CD8 + T cells showed significant tumor growth despite being functionally active, indicating that CD8 + cells must be a key part of exercise to help prevent certain cancers while working.

To further confirm, the scientists then isolated CD8 + T cells from animals that were already running and animals that were not running. Then, they injected one or another type of T cell into a sedentary animal prone to cancer. Subsequently, animals immunized with immune cells from runners were significantly better than those immunized with immune cells from inactive mice.

Randall Johnson, a professor of molecular physiology at the University of Cambridge in England and the Karolinska Institute, who is in charge of the new research, said that these results surprised and excited the researchers. He said that they seem to prove that “the effect of exercise on T cells is inherent in the cell itself and is permanent.”


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