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How Alzheimer's Studies Can Help Patients Be One Step Ahead Of Memory-Deriving Disease



The shocking news that showbiz legend Dame Barbara Windsor has Alzheimer's was fueled by a tidal wave of millions of fans around the world.

The star of Carry On films and EastEnders, 80, was diagnosed four years ago, but her husband, Scott Mitchell, decided to speak now because her symptoms – memory problems and changes in her behavior – became more pronounced ,

In an emotional interview with The Sun newspaper, he said: "I'm I'm doing this because I want us to go out and if something's wrong, it'll be OK, because people know right now, that she has Alzheimer's and will accept it. Of course, Babs – as you know better ̵

1; is far from being alone: ​​around 850,000 Britons have dementia, with 200,000 new cases each year, and one in three people born today is expected to suffer from dementia Develop condition that gradually deprives those affected of their mental abilities.

And although there is no cure for dementia, there is hope.

  The shocking news of showbiz legend Lady Barbara Windsor has given Alzheimer's a tidal wave of millions Pictured: Barbara with her husband Scott Mitchell

The shocking news that showbiz legend Lady Barbara Windsor has Alzheimer's was e Tidal wave of support from millions of fans around the world. Pictured: Barbara with her husband Scott Mitchell

Today British experts are leading a large and concerted medical effort to better treat dementia in all its forms – and the message from doctors is that by engaging, patients have the best possible Become a chance to stay healthy longer.

John O'Brien, a professor of geriatric psychiatry at the University of Cambridge and chairman of the Advisory Council for Clinical Trials of Alzheimer's Research UK, said, "There are more than 150 studies on dementia that has taken place in the UK It is one of the first in the world to have access to new treatments. "

For anyone who considers a medical guinea pig to be risky, he added: The tests are properly regulated to minimize the risk and people are closely monitored. The safety of medicines is already proven in studies that affect actual patients. "

Clive Ballard, Professor of Age Related Diseases at the University of Exeter, agrees:" Patients taking part in a clinical trial are likely to get a better result because they are closely monitored. "

Visit the website www.alzheimersresearchuk.org

For those interested in taking part in a study, the National Health Research Institute of the National Health Research Institute (NHS) has launched" Join Dementia Research, "a source

With their help, here are some of the most promising NHS-supported dementia studies that are currently recruiting and explaining how you or a loved one could benefit …

WHAT IS ALZHEIMER?

Alzheimer's disease is a progressive, degenerative disease of the brain that causes abnormal proteins to cause nerve cells to die.

This interrupts the transmitters that carry messages and causes the brain to shrink.

More than 5 million people suffer from the disease in the US, where it is the sixth most common cause of death che is.

WHAT HAPPENED?

When brain cells die off, their functions are fulfilled are lost.

This includes memory, orientation and the ability to think and argue.

The progress of the disease is slow and gradual.

On average, patients live five to seven years after diagnosis, but some may live for ten to fifteen years

EARLY SYMPTOMS:

  • Loss of short-term memory
  • Disorientation
  • Behavioral changes
  • Mood swings
  • Difficulty handling money or calling

LATER SYMPTOMS:

  • Serious memory loss, forgotten family members, familiar objects or places
  • Fear and frustration over inability to make sense of the world, lead to aggressive behavior
  • Occasionally Ability to Run Lose
  • May Have Problems Eating
  • The majority may require 24-hour care

Source: Alzheimer's Association

The Diabetes Pill That Offers Hope

WHAT

Those with type 2 diabetes are much more likely to develop Alzheimer's and others nd some studies have shown that the diabetes drug liraglutide was developed to combat the blockade d sugar levels, actually improves Alzheimer's symptoms

WHO IS IT?

The ELAD study (investigating liraglutide in Alzheimer's disease) is currently recruiting patients with early-stage Alzheimer's disease in 24 UK locations.

HOW IT CAN HELP

Insulin, a hormone primarily involved in the control of blood sugar levels, is also responsible for helping nerve cells to work. "In Alzheimer's disease, nerve cells seem to be unresponsive to insulin," says Paul Edison, senior clinical lecturer and consultant at Imperial College London. "We know that liraglutide is safe and available for the treatment of diabetes, so if it proves effective for dementia patients, it could be available very quickly. & # 39;

  • Email memory@imperial.ac.uk [19659037] A drug that slows down memory loss

    WHAT

    The global CREAD study is investigating the drug crenezumab, which can slow down memory loss by targeting the abnormal protein that develops in the brains of people with Alzheimer's disease, which leads to the death of brain cells and causes symptoms such as memory loss, mood swings and communication and thinking problems.

    WHO IS IT FOR [?] [19659002] Patients aged 50 to 85 years with early Alzheimer's or memory or thought disorders that may be early symptoms of Alzheimer's disease.

    LIKE IT HELP CAN

    "We work with people who are at a very early stage of Alzheimer's disease and hope to slow the progression of the disease," says Professor Iracema Leroi, a professor of psychiatry at the University of Manchester. "We hope to slow down the deterioration in cognitive abilities and daily functioning as a result of the progression of Alzheimer's disease, and if this treatment is effective, it will make a significant difference to the lives of people living with the disease and their loved ones

    Exercise May Be the Best Medicine

    WHAT

    The TACIT trial aims to improve the health and well-being of people with dementia, using the age-old form of exercise known as t'ai chi

    WHO IS IT?

    The process recruits 150 people with dementia in the Southampton and Dorset areas along with their informal caregiver.

    HOW IT CAN HELP

    People with dementia are often excluded from exams, including t'ai chi trials, "says Dr. Samuel Nyman, NIHR's career developer at Bournemouth University," but There is good evidence that T'ai Chi is beneficial for health conditions including stroke and arthritis.

    "T & # 39; ai Chi can attract attention and improve attention, and make it less frustrated as well with helping to balance and reduce the fear of falling. It's also good to have something a patient and a caregiver can do together.

    • research.bournemouth.ac.uk/project/the-tacit-trial/
      About 850,000 Britons have dementia, with 200,000 new cases each year.One out of three people born today is likely to become a condition Some 850,000 Britons have dementia with 200,000 new cases each year, and every one born today is expected to develop a condition that gradually deprives those affected of their mental abilities

    Approximately 850,000 Britons have dementia with 200,000 new cases a year, and every one born today is expected to develop the condition that gradually deprives those affected of their mental faculties

    Aerobic exercise such as walking and running can stop dementia by reducing the shrinking of the child Brain prevents, as the research suggested in November 2017.

    Being active several times a week will maintain the size of the region of the brain Associated with memory, found a study.

    Known as the hippocampus, this region is often one of the first to worsen Alzheimer's

    Lead author Joseph Firth of Western Sydney University said, "When you exercise, you produce a chemical called brain-derived neurotrophic factor (1965). BDNF), which can help to prevent age-related decline by reducing the worsening of the brain.

    "In other words, exercise can be viewed as a brain maintenance program."

    The scientists, from the universities of Western Sydney and Manchester analyzed 14 studies involving a total of 737 participants

    Participants were between 24 and 76 years old, with a median age of 66.

    They consisted of healthy individuals, Alzheimer's patients, and those with mental health problems Depression and schizophrenia

    Examinations of participants' brains were done before and after completion of one Exercise examines how walking or running treadmills.

    The exercise programs lasted between three months and two years, with participants completing two to five sessions a week.

    Support to Stay Social and Active

    WHAT

    The PRIDE Study – Promoting Independence in Dementia – is looking for ways to help people achieve their independence in the early stages Preserving stage of dementia encourages them to remain socially, physically, and mentally active

    WHO IS IT FOR

    People with early-stage dementia in memory clinics across the UK

    LIKE IT CAN HELP

    "People with early stage dementia often give up their favorite pastimes as activities become more difficult and they lose confidence," says Professor Martin Orrell, Professor of Aging and Mental Health at the University of Nottingham [196592002] We have developed a handbook to help people stay physically and mentally active and independent. It's essentially a way to help them regain that trust and make the most of what they can do.

    • joindementiaresearch.nihr.ac.uk

    Common drugs facilitate agitation

    WHAT

    The SYMBAD study on the treatment of dementia in dementia compares two frequently used medications – the antidepressant mirtazapine and carbamazepine, which controls seizures – with a placebo to see if they treat agitation in dementia.

    WHO IS IT FOR

    People over 18 with a diagnosis of probable Alzheimer's and agitation, in nine British centers

    HOW IT CAN HELP

    Agitation and aggression in dementia significantly affect the quality of life and may mean admission to a nursing home or a general hospital, "says Sube Banerjee, Professor of Dementia at Brighton and Sussex Medical School. "Antipsychotics are widely prescribed but work for only 20 percent of people and are associated with significant risks, and there is anecdotal evidence that mirtazapine and carbamazepine can help without the risks of antipsychotics."

    • joindementiaresearch.nihr.ac. uk

    A Gentle Way to Relieve Stress

    WHAT

    Attempts with a new drug, Xanamem, which was discovered at the University of Edinburgh and the overproduction of cortisol – the stress hormone – in areas of the brain that are most affected by Alzheimer's block.

    WHO IS IT FOR?

    The worldwide XanADu study leads people with memory loss to over 50 years in seven locations in the UK.

    HOW IT CAN HELP

    The mechanism This is much gentler than other medications and could therefore perhaps be given ten to 20 years earlier to avoid problems rather than already Dr. Stuart Ratcliffe, scientific director of St. Pancras Clinical Research., 19659045] jointementiaresearch.nihr.ac.uk We all can attend

    WHAT

    The PROTECT study will collect data and support innovative research to improve our understanding of the aging brain and human development of dementia

    WHO IS IT?

    The study recruited at least 25,000 people, ages 50 and older, who have no dementia, will complete reviews annually online over the next decade.

    HOW IT CAN HELP [19659002] "The PROTECT study will tell us a lot more about how certain factors affect our dementia risk," says Clive Ballard of the University of Exeter. 19659002] & # 39; We have developed resources such as the REACT memory and reasoning program. We have also introduced a series of flags that help us determine when people develop mild cognitive impairments that can lead to dementia, and may recommend them to see their family doctor. "


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