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Half of recovered COVID-19 patients report persistent fatigue



Published in ” PLOS One found it.

Led by researchers at Trinity College Dublin, the study involved drawing blood samples from 128 patients in the post-coronavirus outpatient clinic of St. James’s Hospital in Dublin and evaluating the Chalder Fatigue Scale (CFQ-11). CFQ-11 scored fatigue from 9 to 63 points based on a 9-item questionnaire. The higher the score, the more fatigue.

67 of the 128 participants (52.3%) reported fatigue, a common symptom of acute COVID-19 infection, with a median time of 10 weeks after recovery, while 54 participants (42.2%) stated that they had Restored health.

According to the CFQ-11

case definition, 67 of the 128 participants (52.3%) met the fatigue criteria, with an average score of 20. After COVID-19, the level of physical and mental fatigue of participants was higher than that of the general population. , They are lower than the score indicating chronic fatigue syndrome, which is a complex disease that causes extreme fatigue for at least 6 months and has nothing to do with any underlying disease.

Nearly one-third did not return to work

Before the illness, 105 participants (82%) had worked outside the house, but when the study took part, there were still 33 participants (31%) who had not returned to work. The researchers wrote: “This is particularly worrying because it is recommended to resume work four weeks after the virus infection to prevent the disease from getting worse.”

Of the 128 patients, 71 (55%) have been hospitalized for COVID-19 treatment, of which 35 (49%) received the antimalarial drug hydroxychloroquine, and 6 of this subgroup (8.5%) also received cortex The steroid prednisolone.

There is no link between persistent fatigue and hospitalization, supplemental oxygen or intensive care, or the concentration of laboratory biomarkers of inflammation or cell renewal. However, among women and women who were previously diagnosed with depression or anxiety or who reported using antidepressants, the proportion of women who were tired and lingering was disproportionate.

Of the 128 patients, 66 (51.6%) were medical staff, but there was no association between occupation and persistent fatigue. The author said: “The large number of health care workers in our cohort reflects Irish data and the overall demographic data of our institution. Among them, 50% of SARS-CoV-2 positive cases involve health care workers.” “Proportion of health care workers infected with COVID-19 Very high, not only in our cohort, but also internationally, which means this will have a significant impact on the medical system.”

The average age of the participants was 49.5 years; the results of the study were independent of age.

Impaired quality of life, impaired health system function

The author pointed out that the incidence of sustained fatigue in the study was much higher than that reported in 2006 for patients who recovered from Epstein-Barr virus, Q fever or Ross River virus, but a 2009 study reported that 40% of patients experience fatigue 1 year after recovering from coronavirus infection, which causes severe acute respiratory syndrome (SARS).

The author said: “Long-term post-infection fatigue burden will damage the quality of life and will have a significant impact on individuals, employers and medical systems.” “This study highlights the assessment of whether people recovering from COVID-19 have severe fatigue symptoms. The importance of the disease, regardless of the severity of the initial illness, and may determine the population that is worthy of further research and early intervention.”


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