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Gout not associated with increased fracture risk, study results

Gout, a painful inflammatory arthritis, is not associated with increased risk, according to a large study conducted by Keele University and published in CMAJ ( Canadian Medical Association Journal a fracture connected]).

These results contrast with previous studies that found an increased risk of fractures in gout patients

Gout is the most common form of inflammatory arthritis caused by the formation of urate crystals in a joint. It can cause severe pain and swelling in the joints, usually in the base of the big toe, but also in other joints. In the United Kingdom, 2.4% of adults are affected.

There is some evidence that chronic inflammation can increase the risk of fractures.

Keele University researchers conducted a study in the UK with a large primary care database. They included 31

,781 patients with gout who were compared with 1,22961 controls and followed them between 6.8 and 13.6 years until the first diagnosis of a fracture. The fracture rate was similar in individuals with and without gout. In addition, drugs to reduce uric acid levels in gout carriers do not appear to affect or affect the long-term risk of fractures.

"Our use of a nationally representative cohort should not only generalize our study results in the UK, but also in other countries with similar health care systems," writes Drs. Zoe Paskins from the British Primary Research Center for Arthritis Research, Keele University, Staffordshire.

The study was funded by the National Institute for Health Research (NIHR))

"Risk of fragility fracture in patients with gout and the effect of urate-lowering therapy" published May 14, 2018.

Further information:
Gout associated with increased hip fracture risk in women

Further information:
Risk of Fragility Fracture in Patients with Gout and the Effect of Primitive Therapy, Canadian Medical Association Journal (2018). www.cmaj.ca/lookup/doi/10.1503/cmaj.170806

Sources in Journal:
Journal of the Canadian Medical Association

Provided by:
Journal of the Canadian Medical Association

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