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Crispr gene editing may cause big mistakes in human embryos



Scientists have used Crispr gene editing technology in human embryos to try to repair the gene that causes hereditary blindness, and found that the gene has undergone unexpected and unexpected changes, often eliminating entire chromosomes or most of the chromosomes.

The research was published in the journal Cell on Thursday, and at the same time, the international scientific community continues to work on the potential use of Crispr to edit human embryos that will be used to create pregnancy and childbirth.

In September, an international committee sponsored by the National Academy of Medical Sciences, the National Academy of Sciences, and the Royal Society issued a report stating that gene editing technology is not yet ready for this purpose because scientists do not understand the technology. Perform precise repairs without introducing potentially dangerous changes.

Dieter Egli, assistant professor of developmental cell biology at Columbia University and senior author of the study, said: “This research will not prevent the development of the field. However, we must ask how these powerful tools should be handled and under what circumstances. They are safe and effective.”

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Two separate papers published earlier this month show that the ethical debate about whether to allow genetically modified children and under what circumstances continues.


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