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Cerium creates drug precursors beside silver



Cerium creates drug precursors beside silver

A gentle process discovered by Rice University chemists can replace the difficult, silver-based catalysis to generate valuable fluoroketones, which are precursors for drug design and manufacturing. Image Credit: Renee Man / @ chemkitty

Save your silver coins! It is better used in jewelry than catalysts used in medicines.

Scientists at Rice University have developed a greatly simplified method to make fluoroketones, which are precursors for drug design and manufacture and usually require silver catalysts.

Rice chemist Julian West and graduate students Yen-Chu Lu and Helen Jordan proposed a fast and scalable method for the synthesis of fluoroketones, which is still challenging so far And it is expensive to manufacture.

Their open access work is on the cover of the Royal Society of Chemistry magazine on February 21

Chemical newsletter.

The laboratory’s new process replaces silver with cerium-based cerium ammonium nitrate (CAN), which can produce functional precursors in about 30 minutes under mild conditions.

West said: “We can mass produce in the bathtub.”

Cerium has demonstrated this potential in other laboratories, and the fact that the content of cerium in the earth’s crust is 800 times that of silver has made the Rice team very interested.

West said: “Ketone is the gateway functional group in the molecule, which can be used to make different things, such as anti-cancer compounds.” West said that he was funded by the Texas Cancer Prevention and Research Institute in 2019. Last year, 30 people under the age of 30 in science “changed the rules of the game.”

He said: “They are an important foothold for turning into olefins or aromatic rings.” “The important part of this article is that we incorporate fluorine into these fragments. Fluorine is an interesting element with a high content, but in biology Almost no use.

West said: “Fluorine has some extreme properties: it is incredibly negative, so it can retain its electrons.” “This makes it difficult for enzymes in biological processes to be treated in drugs like anticancer molecules. .”

He said that the hydrogen atoms in the drug molecule are easily processed by the liver, but replacing them with fluorine is “like an armor layer at that location.” “This helps the drug last longer in the body, so you don’t have to take too much. This is ideal for chemotherapy.” He pointed out that atorvastatin (aka Lipitor) is the most commonly used in the United States One of the prescription drugs is mixed with fluorine for the same purpose.

West said: “We want to put fluorine in a specific position in the molecule that we know will have an effect, and this ketone functional group allows us to do this.” People have been using silver catalysts, but the process requires a lot of For silver, it takes a long time at high temperature and must be carried out in a carefully controlled nitrogen or argon atmosphere.

He said: “Our process is a cheap barrel chemical reaction. We think the reaction is completed in about five minutes.” “But for safety reasons, we keep it for 30 days.”

The process is highly scalable. West said: “When Yan Chuchu’s formula was tripled, he got the exact same result.” “It’s rare in this kind of reaction.”


The research team found that light-driven catalysts can form olefins used in the manufacture of drugs and agrochemicals


More information:
Yen-Chu Lu et al., through cerium-mediated C-C bond cleavage, rapid and scalable synthesis of fluoroketones, Chemical newsletter (2021). DOI: 10.1039 / D0CC08183C

Provided by Rice University



Citation: Cerium uses silver as a drug precursor (February 26, 2021) Retrieved from https://phys.org/news/2021-02-cerium-sidelines-silver-drug-precursor.html from February 28, 2021

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