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CDV study shows that COVID-19 patients infected half of the families



COVID-19, Coronavirus

Before the 3D printing of SARS-CoV-2 virus particles, the 3D printing of the spike protein of SARS-CoV-2 (the virus that causes COVID-19). The spike protein (foreground protein) allows the virus to enter and infect human cells. In the virus model, the virus surface (blue) is covered with spike protein (red), which allows the virus to enter and infect human cells. Credit: NIH

A study published by the US government on Friday showed that people who develop COVID-19 have infected about half of family members, and adults are only slightly more likely to spread the virus than children.

The Centers for Disease Control and Prevention (CDC) paper is the latest paper attempting to quantify the rate of disease transmission in the family. Previous studies vary widely, but usually indicate that adults are bigger than children.

The CDC’s new study involves the discovery of initial patients with “indexed” or laboratory-confirmed coronavirus infections in Nashville, Tennessee, and Marshfield, Wisconsin, starting in April 2020.

Indexed patients and their families received remote training to complete symptom diaries and obtain self-collected specimens, which were either only nasal swabs or nasal swabs and saliva samples for a period of 14 days.

A total of 191 registered household contacts of 101 indexed patients reported that they had no symptoms on the day the indexed patients became ill.

During the follow-up period, 102 of the 191 contacts were tested positive for SARS-CoV-2, and the “secondary infection rate” was 53%.

The secondary infection rate of index patients over 18 years of age was 57%, and the secondary infection rate of index patients under 18 years of age dropped to 43%.

Overall, there are far fewer index patients in children than adult patients: 20 people compared to 82 people, which makes the results for children under 18 more difficult to generalize.

In terms of family characteristics, the median number of members per bedroom is one, and 69% of indexed patients report spending four hours or more in the same room with one or more family members the day before, and the day after the onset It accounts for 40%.

40% of indexed patients reported sleeping in the same room with one or more family members before the onset, and 30% after the onset.

Above report

The authors of the paper explained these findings: “In this ongoing prospective study that includes systematic and daily follow-up, the spread of SARS-CoV-2 among family members is very common, and the secondary infection rate is higher than previously reported. Level. .”

They added: “Regardless of whether the index patient is an adult or a child, a large amount of transmission has occurred.”

Another important finding of the study is that less than half of the family members diagnosed with the infection reported symptoms when the infection was first detected, and many people were asymptomatic during the 7 days of follow-up.

This emphasizes the spreading potential of asymptomatic secondary exposure.

Other studies conducted abroad have sometimes found that household infection rates are low.

The CDC said this may be because these studies did not have sufficient follow-up, or because these patients were isolated in facilities outside the house or used stricter masks.

It recommends that people who think they may have COVID-19 be isolated from their families, including sleeping alone and using a separate bathroom if possible, and wearing a mask.

The exposed person should not delay separation until their infection is confirmed by testing.

An important limitation of the study is that determining who is to index patients can be challenging.

When the calculation method was changed to exclude 54 household members, the selected samples of these households were positive, but the results will take time to be determined, so the overall secondary infection rate dropped to 35%.

However, people still think that the first person to show symptoms is the index patient.


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©2020 AFP

Citation: COVID-19 patients infected half of the families: CDC study (October 30, 2020) from https://medicalxpress.com/news/2020-10-faster-wider-covid-households.html on October 31, 2020 Search

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