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Are you in a hurry to develop drugs?This is your chat



Are you in a hurry to develop drugs?This is your chat

Scientists at Rice University developed cHAT to simplify the process of reducing olefins into intermediate molecules useful for drugs and other useful compounds.Credit: Western Laboratory/Rice University

We call it the two-step method of Texas, but it is limited to molecular analysis.


Scientists at Rice University have developed a method to reduce olefins (molecules used to simplify synthesis) into more useful intermediates for drugs and other compounds through a two-catalyst technique called cooperative hydrogen atom transfer or cHAT.

The method can hydrogenate olefins, hydrocarbons containing carbon-carbon double bonds in a simpler and more environmentally friendly way.

Rice chemist Julian West and postdoctoral researcher Padmanabha Kattamuri work in Journal of the American Chemical Society.

In each step, the catalyst donates one electron and one proton. The shocking thing is that both reactions occur in a synergistic process, and the second catalyst takes over immediately after the first is completed.

West said: “The basic reaction of hydrogenation is very useful for making molecules.”

; West joined Rice last year with funding from the Cancer Prevention and Research Institute of Texas (CPRIT). “There are some elements that are really good at this feature and can make many different conversions, but they are very expensive and not the most sustainable.”

Because cHAT uses the earth’s abundant iron and sulfur as catalysts, its cost is much lower than the industry standard methods that rely on expensive precious metals (such as platinum, palladium, gold, and silver) and hydrogen and oxidants that generate toxic waste.

The goal is to make it easier for hydrogen atoms to react with other selected molecules to form new compounds. The cHAT process does not add any oxidants, can be used with a variety of substrates, and is highly scalable. The two-catalyst method can also produce hydrogenated diastereomers, or another form of the same product molecule that noble metals cannot make.

West uses a baseball metaphor to describe the cHAT. He said: “If you remember’Moneyball’, then you know that instead of trying to hire a superstar who can do everything but very expensive, it is better to hire some players and have them work together to achieve a similar transformation. s Choice.”

West said: “In addition, through teamwork, we have introduced a strategy that allows us to adapt to new changes in the product.” “By combining cheap iron with organic sulfur compounds, we can piece together a very A good win-win situation. The iron catalyst accelerates the process by providing it with a hydrogen atom and prevents it. Then sulfur can come in and give it a second one.”

He pointed out that flammable hydrogen is a common reagent in industrial hydrogenation​​. West said: “Our process uses this simple, stable reagent phenylsilane as a hydrogen source.” “We just add it to ethanol along with the catalyst and olefins. Ethanol is also a green solvent.

He said: “When you produce medicines in tons, you have to avoid generating large amounts of toxic solvent waste.” “This is something to avoid at all costs. Therefore, this is a huge victory for pharmaceutical companies.”

He said that his laboratory is working hard to configure its catalysts to produce various products. West said: “This will allow us to get a lot of chemical complexity and diversity from a single raw material.” “We want to know if we can have this high degree of control over the process.”


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More information:
Padmanabha V. Kattamuri and others, “Olefin Hydrogenation through Cooperative Hydrogen Atom Transfer”, Journal of the American Chemical Society (2020). DOI: 10.1021 / jacs.0c09544

Provided by Rice University

Citation: Anxious to develop drugs?This is your HAT (2020, October 30), retrieved from https://phys.org/news/2020-10-drugs-chat.html to October 31, 2020

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